p-ISSN: 1300-0551
e-ISSN: 2587-1498


Department of Physical Education, Varamin-Pishva Branch, Islamic Azad University, Varamin-IRAN

Keywords: Immune system, exhaustion, immunoglobins, cytokines, exercise


In vivo depletion of lymphocyte subsets allows investigation of the role of specific subsets in protective immunity. The immune system has potent intracellular mediators that regulate inflammatory and immune response. This study examined the effect of exhausting exercise on IgA and TNFα in 20 recreationally active female volunteers of normal health, with no positive clinical finding. After fully explaining the procedures, their written consent was taken. Following physical measurements and VO2max determination, subjects performed an exhaustive exercise according to the Bruce protocol. Blood samples were obtained before and following the exercise. Statistical analysis revealed that IgA concentrations increased significantly, and TNFα levels remained stable. The observed effect of exhaustive exercise may be transient and related with intensity and duration. The results suggest that the given exhaustive exercise can not induce suppression of the immune function.